Circulating miR-19b-3p levels were measured in CRC patient samples and correlated with clinicopathological parameters.<h4>Results</h4>miR-19b-3p promoted epithelial-to-mesenchymal transition (EMT) in HCT116 cells by suppressing ZMYND11 and activating the MAPK pathway. The gene discussed is ZMYND11; the disease is colorectal carcinoma.