APP and Alzheimer disease: We hypothesized that VFR removal in AD mice would improve metabolism and cognition.<h4>Methods</h4>Male and female APP<sup>NL-F</sup> mice underwent sham or vWAT surgical resection (periovarian or epididymal and perirenal) at 4 (pre-symptomatic) and 16 (symptomatic) months of age to understand interventional and therapeutic effects, respectively.