SLC5A2 and type 2 diabetes mellitus: This study evaluates dose-dependent effects across HbA1c and renal function strata.<h4>Objective</h4>To assess the glycemic impact of high- versus low-dose SGLT2 inhibitors in T2DM, stratified by HbA1c and renal function.<h4>Methods</h4>This analysis followed PRISMA guidelines (PROSPERO ID: CRD42024605351).