Exposure of human granulosa cell line (HGrC1) to FF from women with PCOS and obesity was associated with a marked reduction in glycolytic capacity (p < 0.05) and decreased mRNA expression of key glycolytic regulators, including GLUT1, HK2 and LDHA (p < 0.05). Here, SLC2A1 is linked to polycystic ovary syndrome.