This study investigated the role of poly (ADP-ribose) polymerase 1 (PARP1) in hyperglycemia-induced podocyte damage and developed a biomimetic targeted siRNA delivery system to silence PARP1.<h4>Methods</h4>Transcriptomic profiling was performed in MPC5 podocytes exposed to high glucose. Here, PARP1 is linked to Hyperglycemia.