Analysis of the constructed prognostic model, immune cell infiltration, and tumor mutational burden (TMB) will facilitate the development of individualized precision medical protocols.<h4>Methods</h4>Based on the LUAD data obtained from TCGA and GEO databases, a prognostic prediction model for LUAD containing 15 key genes (including arginyl aminopeptidase like 1 [RNPEPL1] and beta-1,3-N-acetylglucosaminyltransferase 3 [B3GNT3]) coexpressing with the key NECSO gene, TRPM4, was established.<h4>Results</h4>Risk score was identified as an independent prognostic factor. Here, B3GNT3 is linked to neoplasm.