Therapeutic efficacy was evaluated via anti-NKG2D antibody treatment in murine PF models via histopathology, micro-CT imaging, and molecular profiling of fibrosis markers (collagen-I, fibronectin) and senescence-associated proteins (p-p53, p21).<h4>Results</h4>Significant upregulation of NKG2D on pulmonary NK cells and its ligands on fibroblasts was detected in murine PF. The gene discussed is TP53; the disease is pemphigus foliaceus.