This study investigates the NKG2D-DAP12-SYK-p53-p21 signaling axis as a potential driver of PF through immune-fibroblast interactions.<h4>Methods</h4>We characterized the dynamic expression profile of NKG2D in pulmonary tissues derived from bleomycin (BLM)-induced model mice. The gene discussed is SYK; the disease is pemphigus foliaceus.