Single-cell RNA-seq revealed CD163 expression across all TAM subsets and a compartmentalized distribution of lipid metabolism genes.<h4>Conclusions</h4>Lipid metabolic markers CD36 and CD147 are expressed in ccRCC tumors and correlations with immune cell subsets suggest their role in suppressing anti-tumor immunity. The gene discussed is BSG; the disease is nonpapillary renal cell carcinoma.