Cox regres sion analysis showed that mitotic count (P = .021), tumor rupture (P = .032), Ki67 positivity (P = .032), and GI bleeding (P = .04) were independent factors affecting the relapse-free survival rate of SISTs.<h4>Conclusion</h4>This study shows that SIST patients with GI bleeding are more likely to experience tumor rupture and have higher Ki-67 positivity than those without GI bleeding. Here, MKI67 is linked to Abnormal bleeding.