SKI and metabolic dysfunction-associated steatotic liver disease: SKI, a direct target of miR-3180-3p, when silenced, reversed the protective effects of miR-3180-3p inhibition against FFA-induced cellular damage.<h4>Conclusion</h4>miR-3180-3p is a promising diagnostic biomarker for MASLD and contributes to disease progression by enhancing hepatic inflammation and oxidative stress via targeting SKI.