<h4>Background</h4>Female sexual dysfunction (FSD) among females with hypertension (HTN) is frequently overlooked, with a reported prevalence of 42.1%.<h4>Objectives</h4>We aimed to determine the impact of beta-blockers (BBs), angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEIs/ARBs), and thiazides on sexual function in hypertensive females.<h4>Methods</h4>A prospective randomized controlled trial enrolled 125 female participants. Here, ACE is linked to hypertensive disorder.