Among the ACLF patients, those with AKI were older, had a higher percentage of combined cirrhosis, hypertension, ascites, HE, gastrointestinal bleeding, abdominal infection, and sepsis, a lower percentage of hepatitis B virus (HBV) infection and the use of anti-hepatitis virus drugs, higher levels of white blood cell (WBC) count, C-reactive protein (CRP), blood urea nitrogen (BUN), SCr, and blood uric acid, and lower levels of hemoglobin, platelet (PLT) count, alanine amino transaminase (ALT), aspartate transaminase (AST), albumin, and estimated glomerular filtration rate (eGFR). The gene discussed is CRP; the disease is Sepsis.