<h4>Introduction</h4>Chronic cerebral hypoperfusion (CCH) is a major contributor to cognitive impairment; however, its underlying mechanisms remain poorly understood.<h4>Methods</h4>We investigated CCH-induced glymphatic dysfunction and neurodegeneration in amyloid precursor protein (APP)/presenilin 1 (PS1) and wild-type mice. The gene discussed is PSEN1; the disease is Cognitive impairment.