In patients with aortic stenosis, myocardial and circulating levels of these microRNAs correlated with the severity of left ventricular fibrosis, indicating these microRNAs' potential as new circulating biomarkers of cardiac fibrosis.<h4>Conclusions</h4>In this study, we have newly identified the potential value of microRNA-27b-5p and microRNA-497-5p as actionable biomarkers of the profibrotic response to IL-11 in the heart. Here, IL11 is linked to aortic stenosis.