Findings were further evaluated in transverse aortic constriction and cardiomyocyte-specific <i>Il11</i>-overexpression (Tg-Il11 [transgenic mouse model with cardiomyocyte-specific <i>Il11</i> overexpression]) mouse models and in left ventricular tissue, peripheral plasma, and plasma extracellular vesicles from patients with aortic stenosis.<h4>Results</h4>MicroRNA-27b-5p and microRNA-497-5p were identified as novel downstream effectors of IL-11 signaling. Here, IL11 is linked to aortic stenosis.