MBD2 and acute respiratory distress syndrome: This study investigates the role of the N<sup>6</sup>-methyladenosine (m<sup>6</sup>A) demethylase AlkB homolog 5 (ALKBH5) in alveolar macrophages and its subsequent impact on inflammation and autophagy during ARDS pathogenesis.<h4>Methods</h4>Primary mouse alveolar macrophages were stimulated with Lipopolysaccharide (LPS) and transfected with ALKBH5 knockdown or overexpression plasmids.