Type 1 diabetes (T1D) development progresses through well-defined stages based on the presence of islet autoantibodies such as insulin autoantibody, glutamic acid decarboxylase autoantibody, tyrosine phosphatase-like protein IA-2 autoantibody, and zinc transporter 8 autoantibody and glycemic status. Here, INS is linked to type 1 diabetes mellitus.