Critically, estradiol (E2) depletion and FSH elevation were linked to specific thalamic atrophy (e.g., Right Pc), which in turn predicted lower MMSE scores and VAN disruptions.<h4>Conclusion</h4>Perimenopausal HTN is associated with a neuroendocrine-modulated reorganization of the brain's hierarchy. The gene discussed is BRD2; the disease is hypertensive disorder.