A statistically significant negative correlation was observed between HOMA-B and CTRP15 serum levels (rho=-0.356, p=0.024) in Group-A.<h4>Conclusion</h4>In this study, decreased insulin secretion was found to correlate with increased CTRP15 levels in patients with metabolic syndrome and coronary artery disease. The gene discussed is INS; the disease is coronary artery disorder.