The inter group comparison was conducted using analysis of variance, Pearson correlation analysis was used to analyze the correlation between HBP and BUN, Scr, UACR, and eGFR, and receiver operating characteristic (ROC) curve analysis was used to evaluate the specificity and sensitivity of inflammatory indicators, and to evaluate their diagnostic efficiency for DN patients with sepsis.<h4>Results</h4>Compared with DN and T2DM groups, HBP, CRP and PCT were dramatically increased in DN sepsis group (p<0.001), ESR and NE% also higher (p<0.05). This evidence concerns the gene CRP and Sepsis.