SCT and pancreatitis: We tested a repurposed strategy using clinically approved agents for other indications: secretin to stimulate ductal fluid secretion and isosorbide mononitrate (ISMN) to promote ductal outflow via sphincter of Oddi relaxation.<h4>Results</h4>High-dose cerulein induced robust intrapancreatic protease activation but predominantly caused edematous pancreatitis.