Key variables included demographic data, treatment duration, infection control metrics, and white blood cell (WBC) count, C-reactive protein (CRP), and PCT levels, among others, before and after therapy.<h4>Results</h4>Compared with the standard group, the PCT-guided group exhibited significantly greater reductions in WBC, CRP and PCT levels (P&lt; 0.05), shorter antibiotic duration, fewer secondary infections, and improved antibiotic de-escalation rates. The gene discussed is CRP; the disease is infection.