Both PON1 (OR: 10.821, 95% CI: 1.959-59.778, p= 0.006) and AOPP (OR: 190.068, 95% CI: 20.102-1797.148, p&lt; 0.001) were independently associated with DM after adjusting for age, sex, and weight.<h4>Conclusions</h4>AOPP and PON1 may play a significant role in the development and progression of DM. The gene discussed is PON1; the disease is diabetes mellitus.