DHRS2 and gestational diabetes: Immunohistochemistry confirmed significantly elevated DHRS2 protein levels in placentas from GDM patients and GDM mouse models.<h4>Conclusions</h4>These findings emphasize the critical impact of mitochondrial dysfunction on the pro-inflammatory reprogramming of the placental immune microenvironment in GDM, providing potential targets for anti-inflammatory and immunometabolic interventions.