These correlative findings suggest a potential nexus between AARS2, lactate metabolism, protein lactylation dynamics, and innate immune signaling modulation in COAD.<h4>Conclusion</h4>AARS2 correlates with lactylation dynamics, metabolic features, and immune modulation in COAD, suggesting a potential role in lactylation-associated cGAS-STING pathway regulation. Here, AARS2 is linked to colon adenocarcinoma.