Mechanistically, bLF suppressed NETosis by reducing p47phox and MPO expression and, crucially, diminished p47phox phosphorylation in vivo, consistent with reduced NOX2 activation.<h4>Discussion</h4>These findings identify LTF as a critical dynamic regulator of the p47phox-MPO-NETosis axis in LPS-induced ALI. The gene discussed is MPO; the disease is acute respiratory distress syndrome.