LAP3 and neoplasm: Functional assays tested LAP3 overexpression (OE-LAP3) in A549/PC9 cells (qRT-PCR, Western blot, CCK-8, colony formation, wound-healing, Transwell) and a nude-mouse subcutaneous mouse model.<h4>Results</h4>Integrative single-cell and spatial transcriptomic analyses revealed that tumor epithelial and myeloid cells dominate the NSCLC microenvironment and exhibit lineage-specific activation of amino acid metabolic programs.