Single-cell mapping, regulatory network inference, pan-cancer analyses, protein-level validation, and functional assays were conducted to interrogate key molecular drivers.<h4>Results</h4>Three recurrent immune states were identified, including the Wound Healing, IFN-γ Dominant, and Inflammatory subtypes, each exhibiting distinct immune compositions, metabolic features, signalling activities, and clinical trajectories. This evidence concerns the gene IFNG and cancer.