CYBB and periodontitis: The purpose of this study was to elucidate mechanisms by which NADPH oxidase 2 (NOX2) promotes ferroptosis in gingival epithelial cells and contributes to periodontitis <i>in vivo</i>.<h4>Methods</h4>Periodontitis was induced in C57BL/6 mice by silk ligation and an <i>in vitro</i> model was established using lipopolysaccharide derived from <i>Porphyromonas gingivalis</i> (Pg-LPS) -stimulated CA9-22 gingival epithelial cells.