Among these, macrophages demonstrated a significant increase following osteomyelitis, and the infiltration of Mif<sup>+</sup>Cd63<sup>+</sup>, Arg1<sup>+</sup>Sdc4<sup>+</sup>, and Cxcl1<sup>+</sup>Ccl4<sup>+</sup> macrophages significantly increased. Here, CXCL1 is linked to osteomyelitis.