Moreover, Ccl3-Ccr1 and Cxcl2-Cxcr2 ligand-receptors contributed mostly in immune cells.<h4>Conclusion</h4>Our findings tracked the transcriptional dynamics and evolving immune landscape of osteomyelitis, highlighting macrophages as central regulators of disease progression. The gene discussed is CXCL2; the disease is osteomyelitis.