Cellular experiments revealed that reduced DNASE1L3 levels significantly compromised macrophage efferocytosis of apoptotic cells, accompanied by a decrease in M2 macrophage proportion, an increase in M1 macrophage proportion, diminished LOX enzyme activity, and elevated levels of interleukin-1 β and tumor necrosis factor-α.<h4>Conclusion</h4>SLE and CRC exhibit overlapping DEGs, immune profiles, and signaling pathways. Here, LOX is linked to systemic lupus erythematosus.