TXN and diabetes mellitus: In this study, we investigated the role and mechanism of Trx in alleviating high-glucose-induced pyroptosis in Müller cells.<h4>Study design</h4>Serum samples from patients with diabetes, diabetic mice, and Müller cells were used in the study.<h4>Results</h4><i>In vivo</i> and <i>in vitro</i>, high glucose can lead to increased expression of retinal inflammatory factors, morphological damage, and induction of cell pyroptosis.