Flow cytometry analyzed HLA class II surface expression and antigen presentation to CD4<sup>+</sup> T cells (via IL-2 production), with autophagy's role further confirmed using the inhibitor 3-MA.<h4>Results</h4>GA-DM exhibited potent and dose-dependent cytotoxicity against DLBCL cells, with concentrations of 30-40 μM inducing over 60% cell death within 24 h. Here, IL2 is linked to diffuse large B-cell lymphoma.