PIEZO1 and adenomyosis: The <i>PIEZO1</i> promoter was hypermethylated in myometrium from women with adenomyosis, but the treatment with VPA reactivated <i>PIEZO1</i> expression.<h4>Large scale data</h4>N/A.<h4>Limitations reasons for caution</h4>While we demonstrated stiffness-dependent reduction of PIEZO1 expression but an increase in PIEZO2 and OTR expression, the underlying mechanisms for these changes remain unelucidated.