DPP4 and steatosis: To further elucidate its role in the development of MAFLD, we inhibited DPP4 activity with vildagliptin (VILDA) and analyzed the global transcriptomic changes and specific gene and protein gene expression of steatosis-associated genes with and without DPP4 inhibition.<h4>Results</h4>MAFLD-associated pathways such as PPAR and TNF signaling were differentially regulated in hiPSC-derived steatotic HLCs.