IL20RB suppression through small interfering RNA (siRNA) markedly diminished ccRCC cell proliferation and migration.<h4>Conclusion</h4>Heightened IL20RB expression is linked to a dismal prognosis and infiltration of immune cells in ccRCC, indicating its potential importance in the development of immunotherapeutic strategies. Here, IL20RB is linked to nonpapillary renal cell carcinoma.