Heterozygous missense and nonsense mutations in the N-terminal motor and stalk domains are associated with hereditary spastic paraplegia 10 (SPG10) and Charcot-Marie-Tooth disease type 2 (CMT2), while frameshift mutations in <i>KIF5A</i> C-terminal cargo-binding domain are linked to amyotrophic lateral sclerosis (ALS). Here, KIF5A is linked to Autosomal dominant spastic paraplegia type 10.