IFNA2 and encephalitis: In the 13 European, Middle Eastern, and American cohorts available, odds ratios (OR) for WNV encephalitis in individuals with these auto-Abs relative to those without them in a large sample of the general population untested for WNV infection range from ∼20 (OR = 17.7; 95% CI: 13.8-22.8, P < 10<sup>-16</sup>) for auto-Abs neutralizing only 100 pg/ml IFN-α2 and/or IFN-ω to >2,000 (OR = 2,218.4; 95% CI: 125.1-39,337.7, P < 10<sup>-16</sup>) for auto-Abs neutralizing high concentrations of IFN-α2 and high or low concentrations of IFN-ω.