Furthermore, LTQA was associated with the expansion of Tregs and CD103<sup>+</sup> dendritic cells, reduction of OVA-elevated neurokinins [neurokinin A (NKA), neurokinin B (NKB)], and increased abundance of <i>Lactobacillus</i>.<h4>Conclusion</h4>This study indicates that LTQA may confer resistance to allergic airway inflammation by modulating immune responses and gut microbiota supporting the lung-gut axis as a promising target for novel clinical approaches in asthma management. The gene discussed is TAC1; the disease is asthma.