Importantly, after SFC<sup>+</sup> either in EA or AD, the OXT response to social exposure found in SFC<sup>-</sup>AD controls was completely abolished, whereas in SFC<sup>-</sup>EA/57d mice OXT levels positively correlated with social investigation times, indicating social trauma-induced acute and long-lasting dysfunctions of the OXT system. Here, OXT is linked to Alzheimer disease.