For this reason, many physicians are still using the classical two-injection schedule, using premixed insulin in certain areas of the world.<h4>Aim</h4> To assess glycemic control and complication indicators in type 1 diabetic children on premixed or basal-bolus insulin.<h4>Methods</h4> One hundred children aged 2-14 years with type 1 diabetes mellitus were studied at multiple diabetes care centers; fifty were receiving premixed insulin, and the other fifty were on a basal-bolus insulin regimen. The gene discussed is INS; the disease is diabetes mellitus.