It also altered gut hormone levels in healthy participants.<h4>Conclusions</h4>Gut-restricted TAS2R agonism warrants further study for hyperphagia in Prader-Willi syndrome, and in combination with DPP-4 inhibition for obesity.<h4>Clinicaltrials</h4><h4>Gov number</h4>NCT05121441.<h4>Integrated research application system (iras) number</h4>1011885. Here, DPP4 is linked to Prader-Willi syndrome.