Bioinformatic analysis of microarray datasets led to the identification of 10 female-specific hub genes, SLC4A1, THBS1, ITGB3, IL7R, CCR7, SNCA, CTNNB1, SELP, GZMK, and ITGA2B, from DEGs between control and PAH samples in females. The gene discussed is SNCA; the disease is pulmonary arterial hypertension.