The effect of sex on AD-associated proteinopathies and the interaction between sex, CSVD, and apolipoprotein E (APOE) genotype were analyzed using linear mixed-effect models.<h4>Results</h4>In women, higher CAA burden was associated with lower amyloid beta (Aβ) plaques but higher tau tangles density. This evidence concerns the gene APOE and proteostasis deficiencies.