<h4>Aims</h4>To evaluate the efficacy and safety of closed-loop automated insulin delivery (AID) systems with the conventional insulin delivery arm in adults with type 2 diabetes mellitus (T2DM).<h4>Methods</h4>A systematic review and meta-analysis of 10 randomised controlled trials (n = 786; AID: 436, control: 350) was conducted per PRISMA guidelines. The gene discussed is INS; the disease is diabetes mellitus.