INS and Hypoglycemia: No significant differences were found in hypoglycemia (WMD: -0.11%; 95% CI: -0.32, 0.09; -1.6 min/day; P = 0.28), total daily insulin (WMD: +4.80 IU; 95% CI: -1.87, 11.47; P = 0.16), or CV (WMD: -0.52%; 95% CI: -2.08, 1.04; P = 0.52).