<i>Methods:</i> A total of 69 non-diabetic adults aged 35 ± 8.3 years with obesity (BMI 32.3 ± 4.2 kg/m<sup>2</sup>) underwent a 4 h MMTT to define RH, and an intravenous glucose tolerance test (IVGTT) to characterize RH (via insulin sensitivity, the acute insulin response to glucose (AIRg), insulin clearance, and the disposition index). The gene discussed is INS; the disease is obesity disorder.