Here, in both the cerebral cortex of AD mice and Aβ-exposed U251 cells, pro-inflammatory cytokines and HDAC2/3 expression levels were elevated, whereas the levels of creatine phosphate (CP), CCAAT/enhancer-binding protein α (CEBPα) and microRNA34a (miR-34a) were decreased. Here, HDAC2 is linked to Alzheimer disease.