Information is provided that a number of changes in the expression of these genes, for example, Arg18Trp, Ser87Leu, Ala252Thr, and Leu357Val of the <i>ACO2</i> gene, leads to the development of neurodegenerative diseases; mutations rs121913499, rs121913500 in the <i>IDH1</i>, <i>IDH2</i> genes, rs1270341616 and the <i>DLST</i> gene lead to the development of cancer. Here, IDH1 is linked to neurodegenerative disease.