NFE2L2 and neuroblastoma: This study aims to determine the essential components of the methanolic extract of <i>Cornulaca monacantha</i>, and to explore their neuroprotection against lipopolysaccharides (LPS)-induced neuroinflammation in Neuro-2a mouse neuroblastoma cells, and also to investigate the possible underlying molecular mechanism through tracing the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.