In this study, we examined associations between MMP-2 -1306 C/T (rs243865) and MMP-9 -1562 C/T (rs3918242) single-nucleotide polymorphisms, serum levels of MMP-2, MMP-9 and TIMP-1, and the occurrence of insulin resistance in patients in a Polish cohort. Here, MMP9 is linked to Insulin resistance.