Irisin correlated with osteocalcin (r = -0.252, <i>p</i> = 0.007), P1NP (r = -0.187, <i>p</i> = 0.049) and CrossLaps (r = -0.209, <i>p</i> = 0.026) in tumor-free controls. Here, BGLAP is linked to neoplasm.